Deir Sharaf checkpoint is located west of Nablus and south of the settlement of Shavei Shomron, at the entrance to the village of Deir Sharaf on the road leading to Nablus. The checkpoint was activated in early March 2009 after the Beit Iba checkpoint was closed. Palestinians are allowed through the checkpoint , but not for Israelis. Unlike the checkpoints leading to Qalqilya and Tulkarm, crossing of Israeli Palestinians is only allowed on Saturdays.

The checkpoint is located on Route 60 near at the junction with Route 55, near the village of Jit. There was a checkpoint for vehicles passing between the north and south of the West Bank, which was abolished towards 2010. Since then, surprise checkpoints have been set up there from time to time with a police or Border Police vehicle, and vehicles and their passengers are inspected.